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VOLUME 11 , ISSUE 1 ( January-June, 2021 ) > List of Articles

CASE REPORT

Coexistence of Multiple Potentially Malignant Disorders: A Case Report

Akshaya Thiruvalluvan, Jagat Reddy

Keywords : Oral leukoplakia, Oral lichen planus, Oral submucous fibrosis, Potentially malignant disorders

Citation Information : Thiruvalluvan A, Reddy J. Coexistence of Multiple Potentially Malignant Disorders: A Case Report. 2021; 11 (1):26-28.

DOI: 10.5005/jp-journals-10083-0943

License: CC BY-NC 4.0

Published Online: 01-07-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

The oral potentially malignant disorders (PMDs) is a term used to describe the risk of malignancy being present in an oral lesion or condition either during the time of initial diagnosis or at a future date as per the World Health Organization (WHO). The prevalence of PMDs is reported to be 1–5% among the global population. The most common oral PMDs are leukoplakia, oral lichen planus (OLP), and oral submucous fibrosis (OSMF). The coexistence of all there PMDs is a rare presentation. Literature search showed a dearth of case report with all three PMDs. This is a case report of a patient with all three PMDs manifesting in his oral cavity.


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  1. Warnakulasuriya S, Johnson Newell W, Van Der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa: potentially malignant disorders. J Oral Pathol Med 2007;36(10):575–580. DOI: 10.1111/j.1600-0714.2007.00582.x.
  2. Balraj L, Nagaraj T, Nigam H, Tagore S. Erosive lichen planus: a case report. Nagaraj T, ed. J Med, Radiol, Pathol Surg 2017;4(1):11–14.
  3. Khandelwal V, Nayak PA, Nayak UA, Gupta A. Oral lichen planus in a young Indian child. Case reports. 2013;2013:bcr2013010516. DOI: 10.1136/bcr-2013-010516.
  4. Van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med 2003;32(9):507–512. DOI: 10.1034/j.1600-0714.2003.00125.x.
  5. Shen ZY, Liu W, Zhu LK. A retrospective clinicopathological study on oral lichen planus and malignant transformation: analysis of 518 cases. Med Oral Patol Oral Cir Bucal 2012;17(6):e943–e947. DOI: 10.4317/medoral.17778.
  6. Fitzpatrick SG, Hirsch SA, Gordon SC. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc 2014;145(1):45–56. DOI: 10.14219/jada.2013.10.
  7. Arakeri G, Brennan PA. Oral submucous fibrosis: an overview of the aetiology, pathogenesis, classification, and principles of management. Br J Oral Maxillofac Surg 2013;51(7):587–593. DOI: 10.1016/j.bjoms.2012.08.014.
  8. Ranganathan K, Devi MU, Joshua E, Kirankumar K, Saraswathi TR. Oral submucous fibrosis: a case-control study in Chennai, South India. J Oral Pathol Med 2004;33(5):274–277. DOI: 10.1111/j.0904-2512.2004.00116.x.
  9. Divya VC, Sathasivasubramanian S. Estimation of serum and salivary immunoglobulin G and immunoglobulin A in oral pre-cancer: a study in oral submucous fi brosis and oral lichen planus. J Nat Sc Biol Med 2014;5(1):90–94. DOI: 10.4103/0976-9668.127294.
  10. Shih YH, Wang TH, Shieh TM, Tseng YH. Oral submucous fibrosis: a review on etiopathogenesis, diagnosis, and therapy. Int J Mol Sci 2019;20(12):2940. DOI: 10.3390/ijms20122940.
  11. Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ, Warnakulasuriya S. Oral submucous fibrosis: review on aetiology and pathogenesis. Oral Oncol 2006;42(6):561–568. DOI: 10.1016/j.oraloncology.2005.08.005.
  12. Liu B, Shen M, Xiong J, Yuan Y, Wu X, Gao X, et al. Synergistic effects of betel quid chewing, tobacco use (in the form of cigarette smoking), and alcohol consumption on the risk of malignant transformation of oral submucous fibrosis (OSF): a case-control study in Hunan Province, China. Oral Surg Oral Med Oral Pathol Oral Radiol 2015;120(3):337–345. DOI: 10.1016/j.oooo.2015.04.013.
  13. Haider SM, Merchant AT, Fikree FF, Rahbar MH. Clinical and functional staging of oral submucous fibrosis. Br J Oral Maxillofac Surg 2000;38(1):12–15. DOI: 10.1054/bjom.1999.0062.
  14. Gupta S, Jawanda MK. Oral lichen planus: an update on etiology, pathogenesis, clinical presentation, diagnosis and management. Indian J Dermatol 2015;60(3):222–229. DOI: 10.4103/0019-5154.156315.
  15. Gonzalez-Moles MA, Scully C, Gil-Montoya JA. Oral lichen planus: controversies surrounding malignant transformation. Oral Dis 2008;14(3):229–243. DOI: 10.1111/j.1601-0825.2008.01441.x.
  16. Silverman S, Gorsky M, Lozada F. Oral leukoplakia and malignant transformation. Cancer 1984;53(3):563–568. DOI: 10.1002/1097-0142(19840201)53:33.0.co;2-f.
  17. Nair SN, Holla V, Kini R, Rao PK. Bilateral speckled leukoplakia: a case report. Austin J Dent 2017;4(1):1062. DOI: 10.26420/austinjdent.2017.1062.
  18. Palla S, Rangdhol V, Jeelani S, Vandana S. Determinants of malignant transformation of oral potentially malignant disorders” - covering the gaps. J Sci Dent 2015;5:1–17.
  19. Pinas L, Garcia-Garcia A, Perez-Sayans M, Suarez-Fernandez R, Alkhraisat MH, Anitua E. The use of topical corticosteroides in the treatment of oral lichen planus in Spain: a national survey. Med Oral Patol Oral Cir Bucal 2017;22(3):e264–e269. DOI: 10.4317/medoral.21435.
  20. Lodi G, Sardella A, Bez C, Demarosi F, Carrassi A. Interventions for treating oral leukoplakia. In: The Cochrane Collaboration, ed. Cochrane Database Syst Rev 2004. 1.
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