Introduction: Depression is a major problem of mental illness that influences people globally everywhere. Chronic depression could increase the activity of hypothalamic–pituitary–adrenaline (HPA) axis and sympathetic–adreno–medullary (SAM) axis, and system makes the depressive individuals more amenability to various systemic diseases. Depressive disorder could influence the autonomic nervous system that has effect on the salivary gland in which the salivary secretion is controlled by the parasympathetic and sympathetic innervation. Likewise salivary pH changes may invariably affect the oral health. Aim: The aim of this study was to estimate the salivary pH levels in depression before and after antidepressant therapy. Materials and methods: This study includes 40 subjects/groups, and group I (control), group IIA, and group II B (depressive individual's pre- and post-medication of antidepressant medication). Hospital anxiety and depression scale (HADS) was used to assess the depression. The whole saliva was collected in a sterile container by the spitting method of Navazesh, and Salivary pH level was measured using pH meter. Results: Parametric t-test was used for statistical analysis and thus showing statistically insignificant result for salivary.