Journal of Scientific Dentistry

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VOLUME 12 , ISSUE 2 ( July-December, 2022 ) > List of Articles


Association between rs144070672 and Early Childhood Caries: Case–Control Study

Aruna Sharma

Keywords : Caries, Oral health, Pediatric dentistry

Citation Information : Sharma A. Association between rs144070672 and Early Childhood Caries: Case–Control Study. 2022; 12 (2):47-49.

DOI: 10.5005/jp-journals-10083-1033

License: CC BY-NC 4.0

Published Online: 08-05-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Introduction: Genetic factors influence the susceptibility to early childhood caries. This study aims to evaluate the association between rs144070672 and early childhood caries Methods: Two hundred and forty-eight 3–6-year-old children were recruited into the study, of which 124 children were with early childhood caries and 124 children were without early childhood caries. DNA isolation was done from venous blood and polymerase chain reaction was done. These products were sequenced and the genotypes were analyzed. Results: The samples did not reveal any mutant homozygous genotype differentiation. The odds ratio for the heterozygous genotype was 0.495 with 95% confidence intervals being (0.044–5.54) and a p-value of 0.561. Conclusion: Single nucleotide polymorphism rs144070672 does not increase susceptibility to caries in the studied population.

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