Journal of Scientific Dentistry

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VOLUME 3 , ISSUE 1 ( January-December, 2013 ) > List of Articles

Review

Biomarkers –A Diagnostic Tool for Periodontal Diseases

Anitha K, Sakthi Devi S, Arun Kumar A

Keywords : gingival crevicular fluid, periodontitis,biomarkers

Citation Information : K A, S SD, A AK. Biomarkers –A Diagnostic Tool for Periodontal Diseases. 2013; 3 (1):59-65.

DOI: 10.5005/jsd-3-1-59

License: CC BY-NC 4.0

Published Online: 00-06-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

The conventional clinical diagnostic aids which were introduced almost half a century ago continues to function as the basis of diagnosis in clinical practice. Recent advances in biochemistry and molecular sciences brought us to the significance of biomarkers as diagnostic aids. This new advance in medical science for periodontal diagnosis will provide immense benefit in managing periodontitis patients. Biomarkers are tell – tale molecules that can be used to monitor health status, disease onset, treatment response and outcome. These biomarkers can be obtained from various body fluids. Obtaining GCF by non invasive method provides an easy and reliable modality in using GCF as potential source for biomarkers This simple and non- invasive nature of GCF sourcing and its high sensitivity assay development have led to the idea of using the GCF biomarkers as diagnostic aids for periodontal diagnosis.


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  1. Albandar JM, Brunelle JA, Kingman A. Destruc-tive periodontal disease in adults 30 years of age and older in the United States, 1988-1994. J Pe-riodontol 1999; 70:13-29.
  2. Offenbacher, B.M. Odle, R.C. Gray, T.E. Van Dyke Crevicular fluid prostaglandin E levels as a measure of the periodontal disease status of adult and juvenile periodontitis patients. Journal of periodontal research 1984:19; 1-13.
  3. Taba M, Kinney J, Kim AS et al. Diagnostic Bio-markers for Oral and Periodontal Diseases. Dent Clin North America. 2005 July; 49(3): 551.
  4. Offenbacher S, Barros S, Mendoza L, et al. Changes in gingival crevicular fluid inflamma-tory mediator levels during the induction and resolution of experimental gingivitis in humans. J Clin Periodontol 2010;37:324-33.
  5. Page RC R oozbeh Khosravi, Khady Ka, Ting Huang, Saeed Khalili, Bich Hong Nguyen, Belinda Nicolau, and Simon D. Tran 142 Tumor Necrosis Factor-á and Interleukin-6: Po-tential Interorgan Inflammatory Mediators Con-tributing to Destructive Periodontal Disease in Obesity or Metabolic Syndrome J Periodontal Res. 1991 May;26(3 Pt 2):230.
  6. Christgau, M. Moder, D. Hiller, K.A. Dada, A. Schmitz, G. Schmalz. Grow factors and cytokines in autologous platelet concentrate and their correlation to periodontal regeneration outcomes. Journal of clinical Periodontology 2006;33:837-845.
  7. Paivi Mantyla The scientific basis and develop-ment of a matrix metalloproteinas(MMP)-8 specific chair-side test for monitoring of perio-dontal health and disease from gingival crevicu-lar fluid. Academic dissertation for the degree of PhD. To be publicly discussed by the permission of the Faculty of Medicine, University of Hel-sinki.
  8. Eley B.M. and J.D. Manson –Periodontics. 5th ed: Saunders & Elsiever; 2004;55-82.
  9. Ira B. Lamster and John T. Grbic. Diagnosis of periodontal disease based on analysis of the host response. Periodontology 2000; 1995:83-95.
  10. Bartold P.M., A. Sampath Narayanan-Biology of Periodontal Tissues. 1st ed: Chicago; Quin-tessence Publication; 1998;64-79.
  11. Cao C.F. and Smith Q.T Crevicular fluid Mye-loperoxidase at healthy, gingivitis and periodonti-tis sites. Journal of clinical Periodontology 1989; 16:17-20.
  12. Chambers DA, Imrey PB, Cohen R.L., Craw-ford J.M. Alves M.E.A.F., Mcswiggin T.A. A longitudinal study of aspartate aminotransferase in human gingival crevicular fluid. Journal of periodontal research 1991;26:65-74.
  13. Micheal G. Newman, Henry H. Takei, Fermin A. Carranza Carranza's Clinical Perioodntology 10th ed. Missouri: Saunders Publication; 2006;233.
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