Journal of Scientific Dentistry

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VOLUME 4 , ISSUE 2 ( July-December, 2014 ) > List of Articles

ORIGINAL RESEARCH

Expression of Bax in Oral Lichen Planus – An Immunohistochemical Study

Aparna K, Santha Devy A

Keywords : Apoptosis, Bax, Immunohistochemistry,Oral Lichen Planus

Citation Information : K A, A SD. Expression of Bax in Oral Lichen Planus – An Immunohistochemical Study. 2014; 4 (2):3-8.

DOI: 10.5005/jsd-4-2-3

License: CC BY-NC 4.0

Published Online: 00-12-2014

Copyright Statement:  Copyright © 2014; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: Oral lichen planus (OLP) affect a minor percentage of the general population, but the morbity caused by this disease is a cause of concern. Apoptosis is known to occur during the course of OLP. Aims and Objectives: To find the expression of Bax using immunohistochemistry and To find its role in the pathogenesis of oral lichen planus. Methodology: The present study was done using Immunohistochemical procedure on the 21 samples procured from the archival material. The pro-apoptotic marker Baxwas demonstrated and analysed using peroxidase – antiperoxidaseimmunostainingmethod. Results: The results were analysed using the positivity of the immunostaining of the samples. Further the positivity was graded in terms of their staining intensity, distribution and location of stain uptake. The results were subjected to statistical analysis and analysed using a non-parametric analysis, Mann Whitney test and was found to be statistically significant with p value of 0.000. Conclusion: The results obtained in this study suggest that the process of apoptosis occurs in OLP. Hence inhibition of apoptosis in the patients could reduce the severity of the lesions and thus representing new specific targets for treatment of Lichen Planus.


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