The periodontium and periodontal disease activity can be affected by systemic drug therapy. Immunosuppressant drugs are one among such category. These drugs in common, influences the response of gingival and periodontal tissues to bacterial plaque. An extremely effective and most commonly used immunosuppressant drug for organ transplant procedures is cyclosporine A. The drug is also associated with various untoward effects, including gingival overgrowth. Corticosteroids are another major drug category, which may either exert its action as an immunosuppressant or as an anti-inflammatory agent. This review considers the pharmacokinetics, pharmacodynamics, and unwanted effects of immunosuppressants, on the gingival tissues.
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