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VOLUME 8 , ISSUE 2 ( July-December, 2018 ) > List of Articles


The Role of Stromelysin-3 (ST-3) in Progression of Oral Squamous Cell Carcinoma- A Narrative Review

R. Muthukumaran, Vezhavendhan N, Vidyalakshmi S, Santha Devy A, Premlal K R, Gayathri C

Keywords : Oral Sqaumous Cell Carcinoma, Matrix Metallo Proteinases(MMP), Stromelysin-3 (ST3), MMP-11

Citation Information : Muthukumaran R, N V, S V, A SD, K R P, C G. The Role of Stromelysin-3 (ST-3) in Progression of Oral Squamous Cell Carcinoma- A Narrative Review. 2018; 8 (2):29-31.

DOI: 10.5005/jsd-8-2-29

License: CC BY-NC 4.0

Published Online: 21-08-2020

Copyright Statement:  Copyright © 2018; The Author(s).


Matrix metallo proteinases (MMP) are zinc dependent endopeptitases. The role of MMP have been implicated in various physiological and pathological process including oraganogenesis, inflammation, vascular disease, wound healing, auto immune disease and cancer progression. Several MMPs was over expressed in head and neck squamous cell carcinoma (HNSCC) and the MMP found to have correlating with cell proliferation, angiogenesis, invasion, and metastasis. Epithelial–mesenchymal interactions involving cell–cell, cell–Extra cellular matrix (ECM), multistep process of carcinogenesis. ECM remodelling in tumor progression is mediated by MMPs. MMP 1,2,3,7,8,9,10,11,13, and 19 are most over expressed in HNSCC. The role of MMP 11(ST-3) in human breast carcinoma, ovarian cancer are well established whereas the expression of role of MMP 11 in oral squamous cell carcinoma (OSCC) gives varied observations. Hence the current review is aimed to various studies involved the immunohistochemical expression of MMP 11 in OSCC.

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  1. Matrisian LM. The matrix-degrading metalloproteinases. Bioassays 1992;14:455.63.
  2. Birkedal-Hansen H. Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol 1995;7:728.35.
  3. Nagase H, Woessner JF Jr. Matrix metalloproteinases, minireview. J Biol Chem 1999;274: 21491.4.
  4. Dano K, Andreasen PA, Grondahl-Hansen J, Kristensen P, Nielsen LS, Skriver L. Plasminogen activators, tissue degradation, and cancer. Adv Cancer Res 1985;44:139. 266.
  5. Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993;73:161.95.
  6. Savita JK, Kumar BY, Nayak VN. Matrix metalloproteinases in oral squamous cell carcinoma-A review. Journal of Advanced Clinical and Research Insights. 2018 Jul 1;5(4):124.
  7. Matziari M, Dive V, Yiotakis A. Matrix metalloproteinase 11 (MMP-11; stromelysin-3) and synthetic inhibitors. Medicinal research reviews. 2007 Jul;27(4):528-52.
  8. Nakopoulou L, Panayotopoulou EG, Giannopoulou I, Alexandrou P, Katsarou S, Athanassiadou P, et al. Stromelysin-3 protein expression in invasive breast cancer: Relation to proliferation, cell survival and patients' outcome. Mod Pathol. 2002;15(11):1154-61.
  9. Boulay A, Masson R, Chenard MP, El Fahime M, Cassard L, Bellocq JP, et al. High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3 matrix metalloproteinase. Cancer Res 2001;61:2189–93.
  10. Lin CW, Yang SF, Chuang CY, Lin HP, Hsin CH. Association of matrix metalloproteinase-11 polymorphisms with susceptibility and clinicopathologic characteristics for oral squamous cell carcinoma. Head & neck. 2015 Oct;37(10):1425-31.
  11. Hsin C-H, Chou Y-E, Yang S-F, Su S-C, Chuang Y-T, Lin S-H, et al. MMP-11 promoted the oral cancer migration and FAK/Src activation. Oncotarget [Internet]. 2017;8(20):32783.93.
  12. Arora S et al. Stromelysin 3, Ets-1, and Vascular Endothelial Growth Factor Expression in Oral Precancerous and Cancerous Lesions: Correlation with Microvessel Density, Progression, and Prognosis. Clin Cancer Res. 2005;11(6):2272-84.
  13. Soni S, Mathur M, Shukla Nk, Deo Sv, Ralhan R. Stromelysin-3 Expression Is An Early Event In Human Oral Tumorigenesis. Int J Cancer. 2003;107(2):309-16.
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