Aging is a process where decrease of function occurs followed by DNA damage. DNA replication or transcription are affected because of structural damage to DNA, which leads to alteration or elimination of fundamental cellular process. To overcome this defect cell develop certain repair mechanisms. They are Base Excision Repair, mismatch repair, nucleotide excision repair, and double-strand break repair, homologous recombination, non-homologous end joining. Cancer cells can have increased rate of proliferation capacity, reduced apoptosis and increased capacity to invade basement membrane and metastasize. Because of genomic instability of cancer cell they easily break and reform chromosome and stimulate fusion of new oncogene and tumor suppressor gene are inactivated. To overcome this cancer cells should have capacity to withstand DNA damage.
Gorbunova V, Seluanov A, Mao Z, Hine C. Changes in DNA repair during aging. Nucleic acids research. 2007 Oct 2;35(22):7466-74.
Skinner, A.M. and Turker, M.S. (2005) Oxidative mutagenesis, mismatch repair, and aging. Sci. Aging Knowledge Environ., 2005, re3.
Karran, P. (1996) Microsatellite instability and DNA mismatch repair in human cancer. Semin. Cancer Biol., 7, 15–24.
Wilson D.M., III and Bohr, V.A. (2006) The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst).81.
Szczesny, B, Hazra, T.K, Papaconstantinou. J, Mitra, S. and Boldogh, I. (2003) Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases. Proc. Natl Acad. Sci. USA, 100, 10670–10675.
Hanawalt, P.C.(2002) Subpathways of nucleotide excision repair and their regulation. Oncogene, 21, 8949–8956.
Jackson, S.P. (2002) Sensing and repairing DNA double-strand breaks. Carcinogenesis, 23, 687–696.
Helleday, T. (2003) Pathways for mitotic homologous recombination in mammalian cells. Mutat. Res., 532, 103–115. Lieber, M.R. (1999) The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes. Genes Cells, 4, 77–85.
Lieber, M.R., Ma, Y., Pannicke, U. and Schwarz, K. (2003) Mechanism and regulation of human non-homologous DNA endjoining. Nat. Rev. Mol. Cell Biol.,4,712–720.
Gorbunova, V. and Seluanov, A. (2005) Making ends meet in old age: DSB repair and aging. Mech. Ageing Dev., 126, 621–628.