Background and aim: Down syndrome, also denominated as trisomy 21, is a genetic alteration in which the affected individual carries an extra chromosome 21. Down syndrome patients have specific orofacial features such as mouth breathing, open bite, macroglossia, hypodontia, microdontia, anodontia, fissured tongue, malocclusion, low level of dental caries, poor oral hygiene, delayed eruption, small maxilla, retained deciduous teeth. The present review is aimed to evaluate the prevalence of dental anomalies in Down syndrome individuals. Materials and methods: The primary focus of the search was review articles, case report and observational studies explaining the common dental anomalies affecting Down syndrome individuals. Results: One review article, two case reports and twelve observational studies were included to this review. Prevalence of overall dental anomalies in Down syndrome individuals is about 50.47–95.52% and individual percentage of dental anomalies, taurodontism 9.52–85.71%; anodontia 34.69%; delayed eruption 2.04%; conic teeth 14.28%; microdontia 2.04–16.19%; fusion 2.04%; hypodontia 16.19–62%; fissured tongue 78%; retained teeth 10.17%; and teeth agenesis 30–81% were noticed in Down syndrome individuals. Conclusion: Individuals with Down syndrome exhibit high prevalence of dental anomalies compared to normal individuals. The most prevalent dental anomalies among these individuals were taurodontism, anodontia, hypodontia, fissured tongue and teeth agenesis. These outcomes reinforce that dental care should be directed to prevent and/or control problems and to improve oral hygiene status of Down syndrome individuals.
Andersson EM, Axelsson S, Austeng ME, Øverland B, Valen IE, Jensen TA, et al. Bilateral hypodontia is more common than unilateral hypodontia in children with Down syndrome: a prospective population-based study. Eur J Orthod 2013;36(4):414–418. DOI: 10.1093/ejo/cjt063.
Cuoghi OA, Topolski F, de Faria LP, Occhiena CM, Ferreira ND, Ferlin CR, et al. Prevalence of dental anomalies in permanent dentition of brazilian individuals with Down syndrome. Open Dent J 2016;10: 469–473. DOI: 10.2174/1874210601610010469.
Al-Maweri SA, Tarakji B, Al-Sufyani GA, Al-Shamiri HM, Gazal G. Lip and oral lesions in children with Down syndrome. A controlled study. J Clin Exp Dent 2015;7(2):e284–e288. DOI: 10.4317/jced.52283.
Marques LS, Alcântara CE, Pereira LJ, Ramos-Jorge ML. Down syndrome: a risk factor for malocclusion severity? Braz Oral Res 2015;29:44. DOI: 10.1590/1807-3107BOR-2015.vol29.0044.
Moraes ME, Moraes LC, Dotto GN, Dotto PP, Santos LR. Dental anomalies in patients with Down syndrome. Braz Dent J 2007;18(4):346–350. DOI: 10.1590/S0103-64402007000400014.
Van Marrewijk DJ, Van Stiphout MA, Reuland-Bosma W, Bronkhorst EM, Ongkosuwito EM. The relationship between craniofacial development and hypodontia in patients with Down syndrome. Eur J Orthod 2015;38(2):178–183. DOI: 10.1093/ejo/cjv054.
Phadke SR, Puri RD, Ranganath P. Prenatal screening for genetic disorders: suggested guidelines for the Indian scenario. Indian J Med Res 2017;146(6):689–699.
Gallo C, Pastore I, Beghetto M, Mucignat-Caretta C. Symmetry of dental agenesis in Down syndrome children. J Dent Sci 2019;14(1): 61–65. DOI: 10.1016/j.jds.2018.04.003.
Palaska PK, Antonarakis GS. Prevalence and patterns of permanent tooth agenesis in individuals with Down syndrome: a meta-analysis. Eur J Oral Sci 2016;124(4):317–328. DOI: 10.1111/eos.12282.
Reiche W, Párkányi L, Braunitzer G, Nagy K, Kárpáti K. Oligodontia in a teenager with Down syndrome–a case study. Klin Padiatr 2015;227(1):35–37. DOI: 10.1055/s-0034-1384525.
Durković J, Ubavić M, Durković M, Kis T. Prenatal screening markers for Down syndrome: sensitivity, specificity, positive and negative expected value method. J Med Biochem 2018;37(1):62–66.
Singh A, Bhatia HP, Sharma N. Coexistence of fusion and concrescence of primary teeth: in a child with Down syndrome. Spec Care Dent 2017;37(3):147–149. DOI: 10.1111/scd.12218.
Abeleira MT, Outumuro M, Ramos I, Limeres J, Diniz M, Diz P. Dimensions of central incisors, canines, and first molars in subjects with Down syndrome measured on cone-beam computed tomographs. Am J Orthod Dentofacial Orthop 2014;146(6):765–775. DOI: 10.1016/j.ajodo.2014.08.016.
Van der Linden MS, Vucic S, Van Marrewijk DJ, Ongkosuwito EM. Dental development in Down syndrome and healthy children: a comparative study using the Demirjian method. Orthod Craniofac Res 2017;20(2):65–70. DOI: 10.1111/ocr.12139.