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VOLUME 5 , ISSUE 1 ( January-December, 2015 ) > List of Articles

NARRATIVE REVIEW

Determinants of Malignant Transformation of Oral Potentially Malignant Disorders – Covering The Gaps

Santosh Palla, Vishwanath Rangdhol, Jeelani S, Vandana S

Keywords : Potentially malignant disorders (PMDs), Malignant Transformation (MT), Oral epithelial dysplasia (OED), Oral squamous cell carcinoma (OSCC)

Citation Information : Palla S, Rangdhol V, S J, S V. Determinants of Malignant Transformation of Oral Potentially Malignant Disorders – Covering The Gaps. 2015; 5 (1):36-45.

DOI: 10.5005/jsd-5-1-36

License: CC BY-NC 4.0

Published Online: 13-08-2020

Copyright Statement:  Copyright © 2015; The Author(s).


Abstract

Oral potentially malignant disorders (PMDs) are heterogonous group of lesions and conditions which are warned for future occurrence of oral cancer (mostly oral squamous cell carcinoma OSCC). Habits like tobacco or beetle quid chewing, smoking were considered to be the only important aetiologies of PMDs and OSCC. However, considering the updated reports of oral cancers, evidence exits on its occurrence in absence of any habit history or in normal sites as explained by concepts of field cancerization. This alarms for understanding all possible reasons which may determine the nature of a lesion or factors that are associated with malignant transformation to oral cancer. This review shall cover all possible factors that determine the malignant transformation of oral potentially malignant disorders so that a clinician can understand and judge upon on the progress of potentially malignant conditions to oral cancer just by examining the lesion and co-relating with the listed “Determinants of malignant transformation” for PMDs and OSCC.


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