Introduction: Cold sores – herpes labialis infects 90% of people worldwide, of whom only 30% will experience recurrent herpes labialis, which can last up to 10 days. The common treatment protocol for treating herpes labialis is antiviral drugs. Honey is readily available home remedy, herbal and biocompatible extract with antibacterial, antiviral & immune stimulatory effects. The present review is focussed to analyse the efficacy of topical application of honey in treating herpes labialis. Methods and Analysis: The primary focus of the search was on randomised control trail of honey versus acyclovir in the treatment of herpes labialis. The randomised control trail, clinical trials without randomization and other experimental studies were considered. Discussion: Honey is found to have antiviral properties, which is used in the treatment of herpes labialis. The component called NO (nitric oxide) has antiviral property. Reduction in signs and symptoms of herpetic lesions by honey application is due to inhibition of prostaglandin at lesion site. Conclusion: It is concluded that the mean duration healing time of honey is little lesser than acyclovir with the time period of 3-4 days. Pain reduction is comparable with acyclovir and acceptability of honey is good.