Background: In addition to the variations in taper of the full crown preparation, application of de-sensitizer may also result in diminished adhesion of adhesive cements to tooth structures. This study evaluated the effect of two commercially available de-sensitizers on the retention of crowns made on standard and tapered tooth preparations. Methods: Thirty freshly extracted maxillary first premolars were embedded in acrylic resin blocks. They were divided into two groups (n=15). Group I: Prepared with 3 degrees taper. Group II: Prepared with 15 degrees taper. Nickel-chromium copings were cast with a loop at the occlusal surface for tensile testing after luting with resin-modified glass ionomer cement [Fujicem]. Each group was assigned to three subgroups [n= 5 each] according to de-sensitizers used prior to luting. Subgroup I: Systemp^® de-sensitizer [Ivoclor Vivadent], Subgroup II: Oxalate de-sensitizer [Prime Dental^® products Pvt. Ltd.], and Subgroup III: Control [untreated]. One-way Analysis of Variance [ANOVA] was used as the statistical test of significance. Results: In Group I and II, resin-modified glass ionomer cement exhibited greater mean value retention with Systemp de-sensitizer [206.00±8.22 N and 97.00±2.74 N respectively], followed by the control [149.00±4.18 N and 92.00±2. 74 N respectively]. In both, Oxalate de-sensitizer recorded the lowest mean [110.00±3.54 N and 54.00±6.52 N respectively]. Discussion: Following tooth preparation, irrespective of the taper, de-sensitizers not only reduces post-operative tooth sensitivity but also influence the bond strength of the luting agent.