Background: Oral submucous fibrosis are the common Potentially Malignant Disorders prevailing in India. The primary etiological factor include arecanut which contain numerous Reactive Oxygen Species (ROS). Malondialdehyde (MDA) is the end product of lipid peroxidation and it is mutagenic and tumorigenic. Aims and Objectives: To estimate the serum Malondialdehyde level in Oral submucous fibrosis. Methodology: The control group comprised twenty normal individuals (Group 1). The experimental group comprised twenty patients with oral submucous fibrosis (Group 2). Blood samples were obtained and evaluated for serum Malondialdehyde and antioxidants level. Serum Malondialdehyde level was estimated using TBARS assay by Spectrophotometric method. Results: The present study revealed a statistically significant increase in serum MDA level in OSMF patients in comparison with corresponding normal individuals. Conclusion: While the oxidant (Malondialdehyde) levels are increased, indicating the potential role in premalignancy status, it is important to see from a larger sample if these results are reproducable and if so can it be sensitively used in detection of these potentially malignant disorders (Oral submucous fibrosis).
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