Background: Regeneration of periodontium using autologous materialshave been attempted as it addresses safety issues and ensures easy availability. Among the autologous options available, use of platelet concentrates are promising due to ease of procurement, handling and low cost. Platelet-rich plasma (PRP) is an autologous product that is derived from whole blood through the process of gradient density centrifugation. We hereby report a case of chronic periodontitis with intra bony defects in relation 46 and 47 treated with PRP combined with bone grafts with a six month follow up. Methodology: 5ml of patient\'s venous blood was collectedand PRP obtained after centrifugation. The platelet concentrate obtained was used in combination with bone graft in intra bony defect in relation to 46 and 47. Results: A reduction in the Probing pocket depth (PPD) from 7mm (Pre-operative) to 3mm and CAL (clinical attachment level) from 9 mm (Pre-operative) to 5 mm at 6 month recall was observed respectively. Conclusion: Significant improvement in clinical parameters such as PPD, CAL indicates success of regenerative therapy using PRP with bone grafts.
Giannobile WV. The potential role of growth and differentiation factors in periodontal regeneration J Periodontol 1996; 67:545–553.
Klokkevold, PR, Jovanovic, SA: Advanced Implant Surgery and Bone Grafting Techniques. In Newman, Takei, Carranza, editors: Carranza's Clinical Periodontology, 9th Edition. Philadelphia: W.B. Saunders Co. 2002. Pg. 907-8.
Peterson B, MD, Peter G. Whang, MD et al; Osteoinductivity of Commercially Available Demineralized Bone Matrix; J. Bone Joint Surg. Am 2004;86: 2243-2250.
Blumenthal N, Sabet T, Barrington E. Healing responses to grafting of combined collagen. J Periodontol 1986; 57: 84-94.
Froum SJ, Wallace SS, Tarnow DP, Effect of Platelet-Rich Plasma on Bone Growth and Osseointegration in Human Maxillary Sinus Grafts: Three Bilateral Case Reports. Int J Periodontics Restorative Dent Vol 22. Number 1, 2002. 45-55.
Kazuhiro Okuda, Hideaki Tai, Kiyoshi Tanabe, Hironbu Suzuki, Tadashi Sato, Tomoyuki Kawase et al. Platelet- rich plasma combined with a porous hydroxyapatite graft for the treatment of intrabony Periodontal Defects in Humans: A comparative Controlled Clinical Study. J Periodontol 2005; vol:76.890-898.
Marx RE, Carlson ER, Eichstaedt RM et al. Platelet-rich plasma: Growth factor enhancement for bone grafts Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998: vol:85, 638-646.
Sachin S shivanaikar, Mohammed faizuddin, Treatment of periodontal bony defect with bovine derived xenograft and in combination of platelet rich plasma – A Case report. AOSR 2012;vol:2 (2);98-102.
Wiltfang J, Kloss FR, Kessler P, Nkenke E, Schultze-Mosgau S, Zimmermann R, et al. Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. An animal experiment. Clin Oral Implants Res. 2004; vol:15: 187-193.
Mahantesha, KS Shobha, Clinical and radiographic evaluation of demineralised bone matrix as a bone graft material in the treatment of human periodontal intraosseous defects. J Ind Soc Periodontol; 2013, vol:17, issue:4, page495-502.
Garret S, Periodontal regeneration around natural teeth. Ann Periodontol 1996;vol:1:638-9.