Residual infection in root canal system has always been an area of penumbra for a treating dentist. Lesion sterilization and tissue repair (LSTR) therapy is an endodontic treatment procedure that involves non-instrumentation or minimal instrumentation followed by placement of antibiotic mixture to disinfect root canal systems. It is evolving as an alternate treatment procedure in comparison to traditional pulpectomies/root canal treatment and extractions for treatment of nonvital or pulpless teeth. This article reviews the rationale of the technique, evolution, indications, uses and clinical procedures required in performing the technique.
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