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VOLUME 8 , ISSUE 1 ( January-June, 2018 ) > List of Articles

REVIEW ARTICLE

Effectiveness of Tacrolimus over Triamcinolone Acetonide in The Treatment of Oral Lichen Planus

Ashna Mariya Benny, S. Laxmipriya, Vezhavendhan N

Keywords : Tacrolimus, Triamcinolone acetonide, oral lichen planus

Citation Information : Benny AM, Laxmipriya S, N V. Effectiveness of Tacrolimus over Triamcinolone Acetonide in The Treatment of Oral Lichen Planus. 2018; 8 (1):16-18.

DOI: 10.5005/jsd-8-1-16

License: CC BY-NC 4.0

Published Online: 20-08-2020

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Aim: The aim of the review article was to compare the efficacy of topical Tacrolimus ointment with that of Triamcinolone acetonide ointment on patients suffering from oral lichen planus. Materials and method: A review study was done to analyse the efficacy of topical Tacrolimus ointment with that of Triamcinolone acetonide ointment on patients suffering from oral lichen planus. Over 5 articles were referred from Pubmed and Google database meeting our eligibility criteria (August 2006 - December 2016). A total of 240 patients who were clinically diagnosed with Oral Lichen Planus from a total of 5 studies with 3 randomized control trials and 2 clinical trials were included for this review. Result: Tacrolimus belongs to macrolide family and is caused by streptomycin tukubaensis. It inhibits the activation and proliferation of T-lymphocytes by inhibiting the phosphatase activity of calcineurin. The articles used for the review conclude that the application of Topical Tacrolimus helps in the alleviation of all clinical symptoms in over 80% of the patients under study.

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  1. Manjunatha M Revanappa, Venkatesh G Naikmasur, Atul P Satt. Evaluation of Efficacy of Tacrolimus 0.1% in Orabase and Triamcinolone Acetonide 0.1% in Orabase in the Management of Symptomatic Oral Lichen Planus Randomized Single Blind Control Study. Journal of Indian Academy of Oral Medicine and Radiology. 2012;24(4):269-27.
  2. Ronald Laeijendecker, Bhupendra Tank, Sybren K. Dekker and H. A. Martino Neumann. A Comparison of Treatment of Oral Lichen Planus with Topical Tacrolimus and Triamcinolone Acetonide Ointment. Acta Derm Venerol 2006;86:227-229.
  3. Arash azizi, shirin lawaf. The comparison of efficacy of adcortyl ointment and topical tacrolimus in treatment of erosive oral lichen planus. J Dent Res Dent Clin Dent, 2007;1(3):99-102.
  4. Javed a qazi. Treatment of oral lichen planus with topical Tacrolimus and triamcinolone acetonide ointment - a comparative study. Pakistan oral & dental journal 2010;30:19-21.
  5. M Spionen L Huuskonen, Skallio-Pulllinen, Pnieminen, T Salo. Topical tacrolimus, triamcinolone acetonide, and placebo in oral lichen planus: a pilot randomized controlled trial. Oral Dis 2017 Jul;23(5):660-668.
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