The Role of Stromelysin-3 (ST-3) in Progression of Oral Squamous Cell Carcinoma- A Narrative Review

R. Muthukumaran; Vezhavendhan N; Vidyalakshmi S; Santha Devy A; Premlal K R; Gayathri C

doi:10.5005/jsd-8-2-29

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The Role of Stromelysin-3 (ST-3) in Progression of Oral Squamous Cell Carcinoma- A Narrative Review

R. Muthukumaran, Vezhavendhan N, Vidyalakshmi S, Santha Devy A, Premlal K R, Gayathri C

Keywords : Oral Sqaumous Cell Carcinoma, Matrix Metallo Proteinases(MMP), Stromelysin-3 (ST3), MMP-11

Citation Information : Muthukumaran R, N V, S V, A SD, K R P, C G. The Role of Stromelysin-3 (ST-3) in Progression of Oral Squamous Cell Carcinoma- A Narrative Review. 2018; 8 (2):29-31.

DOI: 10.5005/jsd-8-2-29

License: CC BY-NC 4.0

Published Online: 21-08-2020

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Abstract

Matrix metallo proteinases (MMP) are zinc dependent endopeptitases. The role of MMP have been implicated in various physiological and pathological process including oraganogenesis, inflammation, vascular disease, wound healing, auto immune disease and cancer progression. Several MMPs was over expressed in head and neck squamous cell carcinoma (HNSCC) and the MMP found to have correlating with cell proliferation, angiogenesis, invasion, and metastasis. Epithelial–mesenchymal interactions involving cell–cell, cell–Extra cellular matrix (ECM), multistep process of carcinogenesis. ECM remodelling in tumor progression is mediated by MMPs. MMP 1,2,3,7,8,9,10,11,13, and 19 are most over expressed in HNSCC. The role of MMP 11(ST-3) in human breast carcinoma, ovarian cancer are well established whereas the expression of role of MMP 11 in oral squamous cell carcinoma (OSCC) gives varied observations. Hence the current review is aimed to various studies involved the immunohistochemical expression of MMP 11 in OSCC.

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