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VOLUME 8 , ISSUE 2 ( July-December, 2018 ) > List of Articles

REVIEW ARTICLE

Genetic Aspects of Chronic and Aggressive Periodontitis

Sivaranjani KS, Bijivin Raj V, Vinoth Kumar B. Na, Arvina R, Hema P, Ananya Sweta V

Keywords : Gene, Aggressive Periodontitis, Chronic Periodontitis, Polymorphism

Citation Information : KS S, V BR, B. Na VK, R A, P H, V AS. Genetic Aspects of Chronic and Aggressive Periodontitis. 2018; 8 (2):61-68.

DOI: 10.5005/jsd-8-2-61

License: CC BY-NC 4.0

Published Online: 08-08-2020

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Evidence suggests that there is some genetic basis for the periodontal diseases. The molecular abnormality and its genetic inheritance has been established in some cases of generalized aggressive periodontitis. Family studies indicates that this disorder is transmitted by autosomal recessive genes. Recent evidence also suggests that susceptibility to periodontal disease may be related in part to genetically determined immune responsiveness to bacteria. Although specific genetic risk factors have not been identified for the chronic periodontitis, recent studies indicate that there is significant genetic variance in the population. More precise definitions of disease phenotypes will facilitate future genetic epidemiologic studies of the periodontal diseases.


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  1. Gomez RS, Dutra WO, Moreira PR. Epigenetics and periodontal disease: future perspectives. Inflamm Res. 2009; 58(10):625.
  2. Taba M, Jin Q, Sugai JV, Giannobile WV. Current concepts in periodontal bioengineering. Orthod Craniofac Res. 2005; 8(4):292-302.
  3. Kinane DF, Hart TC. Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med. 2003; 14(6):430-49.
  4. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases Lancet 2005;366:1809–1820.
  5. Sofaer JA. Genetic approaches in the study of periodontal diseases. J Clin Periodontol. 1990; 17(7):401-8.
  6. Hart TC. Genetic risk factors for early-onset periodontitis. J Periodontol. 1996; 67(3):355-66.
  7. Michalowicz BS. Genetic and heritable risk factors in periodontal disease J Periodontol. 1994; 65(5):479-88.
  8. Hassell TM, Harris EL. Genetic influences in caries and periodontal diseases. Crit Rev Oral Biol Med. 1995; 6(4):319-42.
  9. Kornman KS, Crane A, Wang HY, Giovlne FS, Newman MG, Pirk FW, et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol. 1997; 24(1):72-7.
  10. Diehl AM, Yang S, Zhu H, Li Y, Lin H, Gabrielson K, Trush MA,. Mitochondrial adaptations to obesity-related oxidant stress. Ar Biochem Biophysics. 2000; 378(2):259-68.
  11. Havemose-Poulsen A, Sorensen LK, Stoltze K, Bendtzen K, Holmstrup P. Cytokine profiles in peripheral blood and whole blood cell cultures associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol. 2005; 76(12):2276-85.
  12. Moreira PR, Lima PM, Sathler KO, Imanishi SA, Costa JE, Gomez RS. Interleukin-6 expression and gene polymorphism are associated with severity of periodontal disease in a sample of Brazilian individuals. Clin Exper Immunol. 2007; 148(1):119-26.
  13. Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML. Epigenetic differences arise during the lifetime of monozygotic twins. Nat Acad Sci. 2005 Jul 26; 102(30):10604-9
  14. Diehl SR, Wang Y, Brooks CN, Burmeister JA, Califano JV, Wang S, Schenkein HA. Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis. J Periodontol. 1999; 70(4):418-30.
  15. Craandijk J, van Krugten MV, Verweij CL, van der Velden U, Loos BG. Tumor necrosis factor -ƒÁ gene polymorphisms in relation to periodontitis. J Clin Periodontol 2002; 29:28-34.
  16. Shapira L, Stabholz A, Rieckmann P, Kruse N. Genetic polymorphism of TNF-a promoter region in families with localized early-onset periodontitis. J Periodontal Res 2001; 36:183-6.
  17. Schulz S, Machulla HK, Altermann W, Klapproth J, Zimmermann U, Glaser C, et al. Genetic markers of tumor necrosis factor alpha in aggressive and chronic periodontitis. J Clin Periodontol 2008; 35: 493-500.
  18. Holla LI, Fassmann A, Augustin P, Halabala T, Znojil V, Vanek J. The association of interleukin-4 haplotypes with chronic periodontitis in a czech population. J Periodontol 2008; 79:1927- 33
  19. Reichert S, Machulla HK, Klapproth J, Zimmermann U, Reichert Y, Glaser C, et al. Interferon gamma and interleukin 12 gene polymorphisms and their relation to aggressive and chronic periodontitis and key periodontal pathogens. J Periodontol 2008; 79:1434-43.
  20. M. Donati, T. Berglundh, A.-M. Hytonen, M. Hahn-Zoric, L.-A. Hanson, and L. Padyukov. Association of the −159 CD14 gene polymorphism and lack of association of the −308 TNFA and Q551R IL-4RA polymorphisms with severe chronic periodontitis in Swedish Caucasians. J Clin Periodontol. 2005; 32(5): 474.479.
  21. N. G. de Menezes and A. P. V. Colombo. Lack of association between the TNF-á −308 (G/A) genetic polymorphism and periodontal disease in Brazilians. Braz Oral Res. 2008; 22(4): 322–327.
  22. Kinane DF, Hodge P, Eskdale J, Ellis R, Gallagher G. Analysis of genetic polymorphisms at the interleukin-10 and tumor necrosis factor loci in early-onset periodontitis. J Periodontal Res 1999; 34:379-86.
  23. Yamazaki K, Tabeta K, Nakajima T, Ohsawa Y, Ueki K, Itoh H, et al. Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis. J Clin Periodontol. 2001; 28:828-32.
  24. E. A. Nicu, U. Van der Velden, V. Everts, A. J. Van Winkelhoff, D. Roos, and B. G. Loos. Hyper-reactive PMNs in FcãRIIa 131 H/H genotype periodontitis patients. J Clin Periodontol. 2007; 34(11):938–945.
  25. W.-L. van der Pol and J. G. J. van de Winkel. IgG receptor polymorphisms: risk factors for disease. Immunogen. 1998; 48(3):222–232.
  26. N. M. van Sorge, W.-L. van der Pol, and J. G. J. van de Winkel. FcãR polymorphisms: implications for function, disease susceptibility and immunotherapy. T Ant. 2003; 61(3): 189–202.
  27. McGuire MK, Nunn ME. Prognosis versus actual outcome. IV. The effectiveness of clinical parameters and IL-1 genotype in accurately predicting prognoses and tooth survival. J Periodontol. 1999; 70(1):49-56.
  28. Loos BG, Leppers-van de Straat VV. U. Fcg receptor gene polymorphisms in relation to periodontitis. J Clin Periodontol. 2003; 31:345-50.
  29. T. Kobayashi, K. Yamamoto, N. Sugita, et al. The Fcã receptor genotype as a severity factor for chronic periodontitis in Japanese patients. J Periodontol. 2001; 72(10):1324–1331.
  30. N. Sugita, K. Yamamoto, T. Kobayashi, et al. Relevance of FcãRIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients. Clin Exper Immunol. 1999; 117(2): 350–354.
  31. Armitage GC, Wu Y, Wang HY, Sorrell J, di Giovine FS, Duff GW. Low prevalence of a periodontitis-associated interleukin-1 composite genotype in individuals of Chinese heritage. J Periodontol. 2000; 71(2):164-71.
  32. Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. J Dent Res. 2003; 82(2):82-90.
  33. Wang C, Zhao H, Xiao L, Xie C, Fan W, Sun S, Xie B, Zhang J. Association between vitamin D receptor gene polymorphisms and severe chronic periodontitis in a Chinese population. J Periodontol. 2009; 80(4):603-8.
  34. Selvaraj P, Chandra G, Jawahar MS, Rani MV, Rajeshwari DN, Narayanan PR. Regulatory role of vitamin D receptor gene variants of BsmI, ApaI, TaqI, and FokI polymorphisms on macrophage phagocytosis and lymphoproliferative response to mycobacterium tuberculosis antigen in pulmonary tuberculosis. J Clin Immunol. 2004; 24(5):523-32.
  35. Zhang J, Sun X, Xiao L, Xie C, Xuan D, Luo G. Gene polymorphisms and periodontitis. Periodontol 2000. 2011; 56(1):102-24.
  36. Nibali L, Parkar M, D'aiuto F, Suvan JE, Brett PM, Griffiths GS, Rosin M, Schwahn C, Tonetti MS. Vitamin D receptor polymorphism (. 1056 Taq-I) interacts with smoking for the presence and progression of periodontitis. J Clin Periodontol. 2008; 35(7):561-7
  37. Nosaka Y, Tachi Y, Shimpuku H, Kawamura T, Ohura K. Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants. Int J Oral Maxillofac Imp. 2001; 17(1):38-43.
  38. Takashiba S, Ohyama H, Oyaizu K, Kogoe-Kato N, Murayama Y. HLA genetics for diagnosis of susceptibility to early-onset periodontitis. J Periodontal Res. 1999; 34(7):374-8.
  39. Bonfil JJ, Dillier FL, Mercier P, Reviron D, Foti B, Sambuc R, Brodeur JM, Sedarat C. A “case control” study on the role of HLA DR4 in severe periodontitis and rapidly progressive periodontitis. J Clin Periodontol. 1999; 26(2):77-84.
  40. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, et al. TLR4 mutations are associated with endotoxin hyper responsiveness in humans. Nat Genet 2000; 25:187-91.
  41. Agnese D, Calvano J, Hahm SJ, Lowry SF. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Disease 2002; 186:1522-5.
  42. Folwaczny M, Glas J, TOROK HP, Limbersky O, Folwaczny C. Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease. Clin Exper Immunol. 2004; 135(2):330-5.
  43. James JA, Poulton KV, Haworth SE, Payne D, McKay IJ, Clarke FM, Hughes FJ, Linden GJ. Polymorphisms of TLR4 but not CD14 are associated with a decreased risk of aggressive periodontitis. J Clin Periodontol. 2007; 34(2):111-7.
  44. Hayashi J, Masaka T, Ishikawa I. Increased levels of soluble CD14 in sera of periodontitis patients. Infect Immunol 1999; 67:417-20
  45. L. I. Holla, D. Buckova, A. Fassman, T. Halabala, A. Vasku, J. Vacha, Promoter polymorphisms in the CD14 receptor gene and their potential association with the severity of chronic periodontitis. J Med Gen. 2002; 39(11):844.848.
  46. Yamazaki K, Ueki-Maruyama K, Oda T, Tabeta K, Shimada Y, Tai H, et al. Single nucleotide polymorphism in the CD14 promoter and periodontal disease expression in a Japanese population. J Dent Res 2003; 82:612-6
  47. Hugot JP, Chamaillard M, Zouali H, Lesage S, CĂzard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nat Gen 2001; 4(11):599-603
  48. Noack B, Gorgens H, Hoffmann TH, Fanghanel J, Eickholz P, Schackert HK. Novel mutations in the cathepsin C gene in patients with pre-pubertal aggressive periodontitis and Papillon-Lefevre syndrome. J Dent Res. 2004; 83(5):368-70.
  49. Ustun K, Alptekin NO, Hakki SS, Hakki EE. Investigation of matrix metalloproteinase 1 - 1607 1G/2G polymorphism in a Turkish population with periodontitis. J Clin Periodontol 2008; 35:1013-9.
  50. Kadlubar F, Hammons GJ. Cytochrome P450 in metabolism of chemical; carcinogens. In: Mammalian Cytochromes P450, eds. 1987; 2. Guengerich FP: 81-30.
  51. Park KK, Kim JS, Park JY, Chung WY, Choi MA, Cho KS. Polymorphisms in genes encoding for enzymes metabolizing smoking-derived substances and the risk of Peridontitis. J Clin Periodontol 2004; 31:959-64
  52. Meisel P, Timm R, Sawaf H, FanghƒÂnel J, Siegmund W, Kocher T. Polymorphism of the N-acetyl transferase (NAT2), smoking and the potential risk of periodontology. Arch Toxicol 2000; 74:343-8
  53. Kocher T, Sawaf H, FanghƒÂnel J, Timm R, Meisel P. Association between bone loss in periodontal disease and polymorphism of N-acetyltransferase. J Clin Periodontol 2002; 29:21-7
  54. Meisel P, Siegemund A, Dombrowa S, Sawaf H, Fanghaenel J, Kocher T. Smoking and polymorphisms of the interleukin-1 gene cluster in patients with periodontal disease. J Periodontol 2002; 73:27-32
  55. Shapira L, Wilensky A, Kinane DF. Effect of genetic variability on the inflammatory response to periodontal infection. J Clin Periodontol 2005; 32:72-86
  56. Cullinan MP, Westerman B, Hamlet SM, Palmer JE, Faddy MJ, Lang NP, Seymour GJ. A longitudinal study of interleukin-1 gene polymorphisms and periodontal disease in a general adult population. J Clin Periodontol. 2001; 28(12):1137-44.
  57. Nibali L. Suggested guidelines for systematic reviews of periodontal genetic association studies. J Clin Periodontol. 2013; 40(8):753-6.
  58. Nield-Gehrig Foundations of Periodontics for the Dental Hygienist 3rd ed. 2011:195-207
  59. Ding C, Ji X, Chen X, Xu Y, Zhong L. TNF-ƒ¿ gene promoter polymorphisms contribute to periodontitis susceptibility: Evidence from 46 studies. J Clin Periodontol. 2014; 41(8): 748- 759.
  60. Hu YY, Liu JH, Jiang GB, Yuan RX, Niu YM, Shen M. Association between interleukin-1ƒÀ gene -511c>t/+3954c>t polymorphisms and aggressive periodontitis susceptibility: Evidence from a metaanalysis. Med Sci Monit. 2015; 21: 1617-1624.
  61. Han MX, Ding C, Kyung HM. Genetic polymorphisms in pattern recognition receptors and risk of periodontitis: Evidence based on 12,793 subjects. Hum Immunol. 2015 Jul;76(7):496-504.
  62. Chrz.szczyk D, Konopka T, Zi.tek M. Polymorphisms of toll-like receptor 4 as a risk factor for periodontitis: A meta-analysis. Adv Clin Exp Med. 2015; 24(6): 1059-70.
  63. Lindhe, Karring, Lang. Genetics in relation to Periodontitis. Clinical Periodontology and Implant Dentistry 2003; 4:387-97.
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