Introduction: Students who pursue a career in dentistry face a demanding academic and clinical curriculum that can result in depression and anxiety. Students are subjected to different kinds of stressors, some being the pressure from academics with an obligation to succeed while studies usually report sources of stress for dentistry students; there is less information on the levels of stress. Aim: The aim is to assess the depression, anxiety, and stress in dental postgraduate students in Indira Gandhi Institute of Dental Sciences, Puducherry. Materials and methods: A cross-sectional questionnaire study was done, and the study samples included all the postgraduates of all nine specialties. Results: Stress was rather general among all the groups of the study participants; certain factors or stressors, such as the amount of assigned work, competition with peers, examination, and grades, lack of confidence to be a thriving student, and fear of facing parents after failure, impede the academic life of these students and had more significance among the groups when compared to others. Conclusion: Dental students have higher levels of depression, anxiety, or stress than the general population, indicating they may be at risk for greater psychological distress. The academic life of the students seemed to be hampered due to various potential stress factors, such as the amount of assigned work, competition with peers, examination, and grades, lack of confidence to be a thriving student, and fear of facing parents after failure. The information from this study should address such issues that arise in the educational setting and help in creating the learning environment design, as well as interventions to support students through this challenging degree.