Background:Euphorbia hirta is a tropical plant common throughout India. It is used to treat cough, fever, asthma, etc. It has anti-inflammatory and antimicrobial properties. This study was conducted to investigate the antimicrobial activity of E. hirta on common oral pathogens. Materials and methods: An in vitro study was conducted to determine the antimicrobial effect of the ethanol extract of E. hirta on the bacteria (Streptococcus mutans, Lactobacillus acidophilus, and Escherichia Coli) and fungi (Candida albicans). The agar well-diffusion method was used to determine the mean zone of inhibition (ZOI). Results:Euphorbia hirta has antibacterial and antifungal activity against S. mutans (ZOI = 11 ± 0.54 mm), L. acidophilus (ZOI = 10 ± 0.04 mm), E. coli (ZOI = 13 ± 0.05 mm), and C. albicans (ZOI = 14 ± 0.59 mm) at concentration of 5 mg/mL. Conclusion:Euphorbia hirta has antibacterial and antifungal properties against common oral pathogens.
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