Journal of Scientific Dentistry

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Volume  13 (2023)
Volume  12 (2022)
Volume  11 (2021)
Volume  10 (2020)
Volume  9 (2019)
Volume  8 (2018)
Volume  7 (2017)
Volume  6 (2016)
Volume  5 (2015)
Volume  4 (2014)
Volume  3 (2013)
Volume  2 (2012)
Volume  1 (2011)
Related articles

VOLUME 12 , ISSUE 2 ( July-December, 2022 ) > List of Articles

ORIGINAL RESEARCH

Association between rs144070672 and Early Childhood Caries: Case–Control Study

Aruna Sharma

Keywords : Caries, Oral health, Pediatric dentistry

Citation Information : Sharma A. Association between rs144070672 and Early Childhood Caries: Case–Control Study. 2022; 12 (2):47-49.

DOI: 10.5005/jp-journals-10083-1033

License: CC BY-NC 4.0

Published Online: 08-05-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Introduction: Genetic factors influence the susceptibility to early childhood caries. This study aims to evaluate the association between rs144070672 and early childhood caries Methods: Two hundred and forty-eight 3–6-year-old children were recruited into the study, of which 124 children were with early childhood caries and 124 children were without early childhood caries. DNA isolation was done from venous blood and polymerase chain reaction was done. These products were sequenced and the genotypes were analyzed. Results: The samples did not reveal any mutant homozygous genotype differentiation. The odds ratio for the heterozygous genotype was 0.495 with 95% confidence intervals being (0.044–5.54) and a p-value of 0.561. Conclusion: Single nucleotide polymorphism rs144070672 does not increase susceptibility to caries in the studied population.

PDF Share
  1. Casamassimo PS, Thikkurissy S, Edelstein BL, Maiorini E. Beyond the dmft: The human and economic cost of early childhood caries. J Am Dent Assoc 2009;140(6):650–657. DOI:10.14219/jada.archive.2009.0250.
  2. Opal S, Garg S, Jain J, Walia I. Genetic factors affecting dental caries risk. Aust Dent J. 2015;60(1):2–11. DOI: 10.1111/adj.12262.
  3. Patir A, Seymen F, Yildirim M, Deeley K, Cooper ME, Marazita ML, et al. Enamel formation genes are associated with high caries experience in Turkish children. Caries Res 2008;42(5):394–400. DOI: 10.1159/000154785.
  4. Ouryouji K, Imamura Y, Fujigaki Y, Oomori Y, Yanagisawa S, Miyazawa H, et al. Analysis of mutations in the amelogenin and the enamelin genes in severe caries in Japanese pediatric patients. Pediatr Den J 2008;18(2):79–85. https://doi.org/10.1016/S0917-2394(08)70126-5.
  5. Olszowski T, Adler G, Janiszewska-Olszowska J, Safranov K, Kaczmarczyk M. MBL2, MASP2, AMELX, and ENAM gene polymorphisms and dental caries in Polish children. Oral Dis 2012;18(4):389–395. DOI: 10.1111/j.1601-0825.2011.01887.x.
  6. Abbasoğlu Z, Tanboğa İ, Küchler EC, Deeley K, Weber M, Kaspar C. et al. Early childhood caries is associated with genetic variants in enamel formation and immune response genes. Caries Res 2015;49(1):70–77. DOI: 10.1159/000362825.
  7. Gerreth K, Zaorsk K, Zabel M, Boryesewicz-Lewicka M, Nowicki M. Chosen single nucleotide polymorphisms (SNPs) of enamel formation genes and dental caries in a population of Polish children. Adv Clin Exp Med 2017;26(6):899–905. DOI: 10.17219/acem/63024.
  8. Wu L, Li Z, Zhou J, Bin M, Fei Y, Xin Z, et al. An association analysis for genetic factors for dental caries susceptibility in a cohort of Chinese children. Oral Dis 2022;28(2):480–494. DOI: 10.1111/odi.13758.
  9. Antunes LA, Antunes LS, Kuchler EC, Lopes LB, Moura A, Bigonha RS, et al. Analysis of the association between polymorphisms in MMP2, MMP3, MMP9, MMP20, TIMP1, and TIMP2 genes with white spot lesions and early childhood caries. Int J Paediatr Dent 2016;26(4):310–319. DOI: 10.1111/ipd.12202.
  10. Weber M, Søvik JB, Mulic A, Deeley K, Tveit AB, Forella J, et al. Redefining the phenotype of dental caries. Caries Res 2018;52(4):263–271. DOI: 10.1159/000481414.
  11. Chaussain C, Bouazza N, Gasse B, Laffont AG, Opsahl Vital S, Davit-Beal T, et al. Dental caries and enamelin haplotype. J Dent Res 2014;93(4):360–365. DOI: 10.1177/0022034514522060.
  12. Gerreth K, Zaorska K, Zabel M, Boryesewicz-Lewicka M, Nowicki M. Association of ENAM gene single nucleotide polymorphisms with dental caries in Polish children. Clin Oral Invest 2016;20:631–636. DOI: 10.1007/s00784-016-1743-1.
  13. Wang M, Qin M, Xia B. The association of enamelin, lactoferrin, and tumour necrosis factor alpha gene polymorphisms with high caries susceptibility in Chinese children under 4 years old. Arch Oral Biol 2017;80:75–81. DOI: 10.1016/j.archoralbio.2017.03.023.
  14. Ganesh A, Muthu MS, Mohan A, Kirubakaran R. Prevalence of early childhood caries in India – A systematic review. Indian J Pediatr 2019;86(3):276–286. DOI: 10.1007/s12098-018-2793-y.
  15. Bartlett JD. Dental enamel development: Proteinases and their enamel matrix substrates. ISRN Dent 2013;2013:684607. Published 2013 Sep 16. DOI: 10.1155/2013/684607.
  16. Hu JC, Yamakoshi Y. Enamelin and autosomal-dominant amelogenesis imperfecta. Crit Rev Oral Biol Med 2003;14(6):387–398. DOI: 10.1177/154411130301400602.
  17. Wright JT. The molecular etiologies and associated phenotypes of amelogenesis imperfecta. Am J Med Genet A 2006;140(23):2547–2555. DOI: 10.1002/ajmg.a.31358.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.